Mesothelioma Info

Summary These NCCN Guidelines focus on MPM, which is the most common type of mesothelioma. This Discussion text for MPM describes the recommendations in the algorithms in greater detail, for example, by including the clinical trial data and other references that support the NCCN Panel’s recommendations in the algorithms. Revisions for the 2018 update are […]

Mesothelioma Radiation Therapy

Radiation Therapy The Principles of Radiation Therapy are described in the algorithm and are summarized in this Discussion (see the NCCN Guidelines for Malignant Pleural Mesothelioma). The NCCN Guidelines for Non-Small Cell Lung Cancer are also a useful resource. In patients with MPM, RT can be used as part of a multimodality regimen; however, RT […]

Mesothelioma Chemotherapy

Trimodality therapy—using mesothelioma chemotherapy, surgery, and hemithoracic RT—has been used in patients with MPM. Median survival of up to 20 to 29 months has been reported for patients who complete trimodality therapy. Nodal status and response to chemotherapy can affect survival. In patients who do not receive induction chemotherapy before EPP, postoperative sequential chemotherapy with […]

Mesothelioma Surgery

It is essential that patients receive a careful assessment before Mesothelioma surgery is performed. Surgical resection for patients with MPM can include either 1) pleurectomy/decortication (P/D; also known as total pleurectomy, lung-sparing surgery), which is complete removal of the involved pleura and all gross tumor; or 2) extrapleural pneumonectomy (EPP), which is en-bloc resection of […]

Mesothelioma Treatment

The NCCN Guidelines recommend that patients with MPM be managed by a multidisciplinary team with experience in MPM. Mesothelioma treatment options for patients with MPM include surgery, radiation therapy (RT), and/or chemotherapy; select patients (ie, clinical stages I–III, medically operable, epithelial histology, good performance status [PS]) are candidates for multimodality therapy. Definitive RT alone is […]

Mesothelioma Symptoms

Mesothelioma Symptoms often have dyspnea and chest pain; they may also have pleural effusion, fatigue, insomnia, cough, chest wall mass, loss of appetite, and weight loss (see the NCCN Guidelines for Adult Cancer Pain, available at NCCN).  Patients with MPM often have a high Mesothelioma Symptoms burden when compared with patients who have other types […]

Whate is Mesothelioma

Mesothelioma is a rare cancer that is estimated to occur in approximately 2500 people in the United States every year. These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines(R)) focus on malignant pleural mesothelioma (MPM), which is the most common type (81%). Mesothelioma can also occur in the lining of other sites, such as the […]